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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - SGC2085 HCl

SGC2085 HCl

CAS No. 1821908-49-9

SGC2085 HCl( —— )

Catalog No. M17389 CAS No. 1821908-49-9

SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SGC2085 HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs.
  • Description
    SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    Coactivator Associated Arginine Methyltransferase 1 (CARM1)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1821908-49-9
  • Formula Weight
    348.87
  • Molecular Formula
    C19H24N2O2·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(=O)([C@H](C)N)NCc1cc(c(cc1)Oc1cc(cc(c1)C)C)C.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Renato., et al. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening . J Med Chem. 2016 Jul 28;59(14):6838-47.
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